Membrane guanylyl cyclase receptors: an update

Molecular Physiology of Membrane Guanylyl Cyclase Receptors.

cGMP controls many cellular functions ranging from growth, viability, and differentiation to contractility, secretion, and ion transport. The mammalian genome encodes seven transmembrane guanylyl cyclases (GCs), GC-A to GC-G, which mainly modulate submembrane cGMP microdomains. These GCs share a unique topology comprising an extracellular domain, a short transmembrane region, and an intracellul...

Guanylyl cyclase receptors mediate cardiopulmonary vagal reflex actions of ANP.

Atrial natriuretic peptide (ANP) potentiates vagal cardiopulmonary reflexes due to chemosensory (Bezold-Jarisch [B-J] reflex) or mechanosensory (ramp baroreflex) activation. The ANP receptor mediating these actions is unknown. We examined the role of particulate guanylyl-cyclase (pGC) receptors in ANP-induced enhancement of cardiopulmonary vagal reflexes. Cardiopulmonary baroreceptor reflex fun...

Guanylyl cyclase-linked natriuretic peptide receptors: structure and regulation.

The regulation and physiological roles of the guanylyl cyclase receptors.

CYCLIC guanosine 3', 5'-monophosphate (cGMP) was the second of the cyclic nucleotide "second messengers" discovered [1-3] and 35 years later, its role in many cells remains unclear. It has been suggested that the rate of cGMP turnover is one means by which this nucleotide signals [4], but most studies suggest cells monitor intracellular cGMP concentrations, which are regulated by guanylyl cycla...

Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes.

OBJECTIVE Although the importance of the cyclic GMP (cGMP) signaling pathway in cardiac myocytes is well established, little is known about its regulation. Ca2+-dependent translocation of nitric oxide (NO) sensitive guanylyl cyclase (GCNO) to the cell membrane has been recently proposed to play a role. The aim of this study was to determine the possible functional relevance of GCNO bound to the...